Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 2/20 | 0.31 |
| ▸ | CPT1A | P50416 | 2/20 | 0.31 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769417 | 1.00 | RAF1 (0.33) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL17769415 | 1.00 | RAF1 (0.33) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL17769734 | 1.00 | RAF1 (0.33) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL17769555 | 0.96 | KIF11 (0.33) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL17769558 | 0.96 | KIF11 (0.33) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL17769675 | 0.94 | KIF18A (0.34) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL20550861 | 0.94 | KIF18A (0.34) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL20550420 | 0.94 | KIF18A (0.34) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL17778372 | 0.94 | KIF18A (0.34) | RAF1BRAFTRPV1RPS6KB1PIK3CA | |
| SCHEMBL17769673 | 0.94 | KIF18A (0.34) | RAF1BRAFTRPV1RPS6KB1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079712-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |