Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | HTR2C | P28335 | 6/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778460 | 0.91 | MTOR (0.42) | MTORHTR2AHTR2C | |
| SCHEMBL17778538 | 0.87 | MTOR (0.41) | MTORPIK3CAHTR2AHTR2CPIK3CG | |
| SCHEMBL17767932 | 0.86 | HTR2A (0.45) | MTORHTR2AHTR2CFAAH | |
| SCHEMBL17768133 | 0.86 | HTR2A (0.42) | MTORHTR2AHTR2C | |
| SCHEMBL17778459 | 0.86 | GSK3B (0.38) | FAAH | |
| SCHEMBL17778469 | 0.86 | ALDH1A1 (0.42) | MTORHTR2AHTR2C | |
| SCHEMBL17767930 | 0.85 | HTR2A (0.39) | HTR2AHTR2C | |
| SCHEMBL17778720 | 0.85 | HTR2C (0.45) | HTR2AHTR2C | |
| SCHEMBL17618719 | 0.84 | ALDH1A1 (0.42) | MTORPIK3CAHTR2AHTR2CPIK3CG | |
| SCHEMBL17767981 | 0.83 | HTR2C (0.44) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2018-11-08 | — | — | US | disclosed |
| WO-2016079712-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | MTOR 363/4885PIK3CA 4009/4885HTR2A 4669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.