Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.32 |
| ▸ | TACR2 | P21452 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778350 | 0.94 | KIF11 (0.36) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17778332 | 0.93 | KIF11 (0.37) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17778333 | 0.90 | KIF11 (0.37) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17778376 | 0.90 | KCNJ6 (0.34) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17778476 | 0.88 | SCN10A (0.36) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17778414 | 0.88 | SCN10A (0.36) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17769729 | 0.85 | KIF11 (0.36) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17769566 | 0.85 | KIF11 (0.36) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17769731 | 0.85 | KIF11 (0.36) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 | |
| SCHEMBL17778473 | 0.83 | TSHR (0.38) | KIF11KCNJ6KCNJ5KCNJ3IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079712-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |