SCHEMBL1777855

SCHEMBL1777855

COc1ccc(CN2CCn3c(cnc3Br)C2)cc1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.50
COMT P21964 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
CHKA P35790 1/20 0.43
PTGIR P43119 1/20 0.43
DRD4 P21917 2/20 0.43
ABCB1 P08183 1/20 0.43
ABCC1 P33527 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.43
POLB P06746 1/20 0.41
PKM P14618 1/20 0.41
CLPP Q16740 1/20 0.41
AURKA O14965 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5776762 0.82 SIGMAR1 (0.49) SIGMAR1COMTDRD4POLB
SCHEMBL21419103 0.79 SMN1; SMN2 (0.55) SIGMAR1COMTSMN1; SMN2DRD4CLPP
SCHEMBL12650256 0.76 SIGMAR1 (0.46) SIGMAR1COMTSMN1; SMN2CLPP
SCHEMBL1778436 0.74 COMT (0.55) SIGMAR1COMTSMN1; SMN2CHKAPTGIR
SCHEMBL20804352 0.73 SIGMAR1 (0.85) SIGMAR1SMN1; SMN2CHKAPTGIRPOLB
SCHEMBL1043952 0.73 SIGMAR1 (0.85) SIGMAR1SMN1; SMN2CHKAPTGIRPOLB
SCHEMBL19285228 0.73 SIGMAR1 (0.85) SIGMAR1SMN1; SMN2CHKAPTGIRPOLB
SCHEMBL24687768 0.70 COMT (0.51) SIGMAR1COMTSMN1; SMN2CHKAPTGIR
SCHEMBL5775595 0.70 SIGMAR1 (0.50) SIGMAR1COMTSMN1; SMN2DRD4POLB
SCHEMBL11394352 0.70 SIGMAR1 (0.72) SIGMAR1SMN1; SMN2CHKAPTGIRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250127792-A1 IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-04-24 US disclosed
US-12186324-B2 Imidazopiperazine inhibitors of transcription activating proteins BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-01-07 US disclosed
CN-112165944-B Imidazopiperazine inhibitors of transcriptional activator proteins 德州大学系统董事会 2024-04-09 CN disclosed
US-20230008047-A1 IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-01-12 US disclosed
US-11058688-B2 Imidazopiperazine inhibitors of transcription activating proteins BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-07-13 US disclosed
CN-112165944-A Imidazopiperazine inhibitors of transcriptional activator proteins 德州大学系统董事会 2021-01-01 CN disclosed
WO-2019191667-A1 IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-10-03 WO disclosed
US-20190298729-A1 IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2019-10-03 US disclosed
US-8309571-B2 Heterobicyclic compounds useful as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2012-11-13 US disclosed
US-8309571-B2 Heterobicyclic compounds useful as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2012-11-13 US disclosed
US-8309571-B2 Heterobicyclic compounds useful as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2012-11-13 US disclosed
US-20110190292-A1 HETEROBICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2011-08-04 US disclosed
US-20110190292-A1 HETEROBICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2011-08-04 US disclosed
US-20110190292-A1 HETEROBICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2011-08-04 US disclosed
US-7943617-B2 Especially p38 MAP kinase alpha and beta; 2,4-difluorophenyl(3-(2-(trifluoromethyl)phenyl)-5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl)methanone BRISTOL-MYERS SQUIBB COMPANY (US) 2011-05-17 US disclosed
US-7943617-B2 Especially p38 MAP kinase alpha and beta; 2,4-difluorophenyl(3-(2-(trifluoromethyl)phenyl)-5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl)methanone BRISTOL-MYERS SQUIBB COMPANY (US) 2011-05-17 US disclosed
US-7943617-B2 Especially p38 MAP kinase alpha and beta; 2,4-difluorophenyl(3-(2-(trifluoromethyl)phenyl)-5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl)methanone BRISTOL-MYERS SQUIBB COMPANY (US) 2011-05-17 US disclosed
US-20080275052-A1 HETEROBICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2008-11-06 US disclosed
US-20080275052-A1 HETEROBICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2008-11-06 US disclosed
US-20080275052-A1 HETEROBICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2008-11-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080275052-A1 HETEROBICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS MAP2K2, MAP2K6, MAP2K1 SIGMAR1 1042/4885COMT 2918/4885SMN1; SMN2 3169/4885
US-11058688-B2 Imidazopiperazine inhibitors of transcription activating proteins EP300, CREBBP, RBBP7 SIGMAR1 4158/4885COMT 4383/4885SMN1; SMN2 3825/4885
US-20230008047-A1 IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS EP300, CREBBP, RBBP7 SIGMAR1 4158/4885COMT 4383/4885SMN1; SMN2 3825/4885
US-20110190292-A1 HETEROBICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS MAP2K2, MAP2K6, MAP2K1 SIGMAR1 1042/4885COMT 2918/4885SMN1; SMN2 3169/4885
US-20250127792-A1 IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS EP300, CREBBP, RBBP7 SIGMAR1 4158/4885COMT 4383/4885SMN1; SMN2 3825/4885
US-12186324-B2 Imidazopiperazine inhibitors of transcription activating proteins EP300, CREBBP, RBBP7 SIGMAR1 4158/4885COMT 4383/4885SMN1; SMN2 3825/4885
US-20190298729-A1 IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS EP300, CREBBP, RBBP7 SIGMAR1 4158/4885COMT 4383/4885SMN1; SMN2 3825/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.