Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.32 |
| ▸ | BTK | Q06187 | 3/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 3/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769600 | 1.00 | KCNJ5 (0.32) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL17778626 | 1.00 | KCNJ5 (0.32) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL17769597 | 1.00 | KCNJ5 (0.32) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL17778317 | 0.96 | KCNK3 (0.33) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL17768086 | 0.96 | KCNK3 (0.33) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL17768085 | 0.96 | KCNK3 (0.33) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL19689788 | 0.96 | KCNK3 (0.33) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL17769326 | 0.94 | KIF11 (0.33) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL17769396 | 0.94 | KIF11 (0.33) | KCNJ5KCNJ3KCNK3BTKTRPV1 | |
| SCHEMBL17769709 | 0.94 | KIF11 (0.33) | KCNJ5KCNJ3KCNK3BTKTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |