Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR1E | P28566 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17776527 | 0.83 | EGLN1 (0.50) | EGLN1PARP1CCNE1CDK2KDM4E | |
| SCHEMBL13667384 | 0.79 | EGLN1 (0.44) | EGLN1PARP1CCNE1CDK2KDM4E | |
| SCHEMBL15753484 | 0.77 | HPGDS (0.47) | CDK2JAK2TYK2 | |
| SCHEMBL13667390 | 0.76 | ATR (0.42) | EGLN1PARP1CCNE1CDK2MAPT | |
| SCHEMBL17778780 | 0.76 | XDH (0.42) | XDHKDM4EMAPTCASP1HTT | |
| SCHEMBL11023230 | 0.75 | BRD4 (0.52) | EGLN1HTTJAK2TYK2ATM | |
| SCHEMBL19706509 | 0.74 | EGLN1 (0.45) | EGLN1PARP1CCNE1CDK2KDM4E | |
| SCHEMBL13667383 | 0.73 | BRD4 (0.57) | MAPTALDH1A1PKM | |
| SCHEMBL13667382 | 0.72 | POLB (0.50) | EGLN1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL3133619 | 0.71 | EGLN1 (0.42) | EGLN1PARP1CCNE1CDK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |