Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 8/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754387 | 1.00 | FAAH (0.44) | FAAHPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17618625 | 0.90 | FAAH (0.42) | FAAHPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL17618518 | 0.86 | PIK3CA (0.39) | FAAHPIK3CDPIK3CAGSK3BDYRK1A | |
| SCHEMBL16754358 | 0.85 | PIK3CA (0.47) | FAAHPIK3CACYP2C19 | |
| SCHEMBL17767960 | 0.85 | FAAH (0.36) | FAAHPIK3CAGSK3BDYRK1ACYP2C19 | |
| SCHEMBL16754550 | 0.85 | FAAH (0.36) | FAAHPIK3CAGSK3BDYRK1ACYP2C19 | |
| SCHEMBL16754332 | 0.85 | WNT3A (0.38) | FAAH | |
| SCHEMBL19706899 | 0.85 | FAAH (0.35) | FAAHPIK3CAGSK3BDYRK1ACYP2C19 | |
| SCHEMBL17768057 | 0.84 | SCD (0.40) | FAAHPIK3CAGSK3BDYRK1ACYP2C19 | |
| SCHEMBL16754501 | 0.84 | FAAH (0.36) | FAAHPIK3CDPIK3CAGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |