Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | BRSK1 | Q8TDC3 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | FLT4 | P35916 | 2/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754326 | 1.00 | MAPT (0.35) | MAPTCYP2C19PIK3CADYRK3PRKD3 | |
| SCHEMBL16754646 | 0.88 | CYP2C19 (0.36) | MAPTCYP2C19PIK3CADYRK3PRKD3 | |
| SCHEMBL17618570 | 0.87 | ALOX15 (0.38) | MAPTCYP2C19PIK3CADYRK3PRKD3 | |
| SCHEMBL16754358 | 0.86 | PIK3CA (0.47) | MAPTCYP2C19PIK3CAFAAHALOX15 | |
| SCHEMBL19669051 | 0.86 | MAPT (0.38) | MAPTCYP2C19PIK3CADYRK3PRKD3 | |
| SCHEMBL16249951 | 0.84 | ABL1 (0.38) | MAPTCYP2C19PIK3CADYRK3PRKD3 | |
| SCHEMBL17618909 | 0.84 | ALOX15 (0.44) | MAPTCYP2C19FAAHALOX15TSHR | |
| SCHEMBL17618560 | 0.83 | WNT3A (0.40) | MAPTMAP4K4GSK3BFAAH | |
| SCHEMBL17618655 | 0.83 | CCNC (0.39) | MAPTCYP2C19PIK3CA | |
| SCHEMBL16754534 | 0.83 | DYRK1A (0.36) | GSK3BDYRK1AFAAHJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |