Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 12/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17780456 | 0.94 | PLK1 (0.38) | PLK1LRRK2TBK1PARP1BRD4 | |
| SCHEMBL17780504 | 0.92 | BRD4 (0.38) | PLK1JAK2LRRK2TBK1PARP1 | |
| SCHEMBL17780372 | 0.92 | ALK (0.35) | PLK1ALKAURKADAPK3JAK2 | |
| SCHEMBL17780376 | 0.92 | ALK (0.35) | PLK1ALKAURKADAPK3JAK2 | |
| SCHEMBL17780575 | 0.92 | JAK2 (0.36) | PLK1ALKAURKADAPK3JAK2 | |
| SCHEMBL17780424 | 0.86 | BRD4 (0.38) | PLK1ALKAURKADAPK3JAK2 | |
| SCHEMBL17780532 | 0.86 | BRD4 (0.38) | PLK1LRRK2TBK1PARP1BRD4 | |
| SCHEMBL17780427 | 0.86 | BRD4 (0.38) | PLK1ALKAURKADAPK3JAK2 | |
| SCHEMBL17780480 | 0.85 | PLK1 (0.39) | PLK1TBK1PARP1BRD4BRDT | |
| SCHEMBL17780482 | 0.85 | PLK1 (0.39) | PLK1TBK1PARP1BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | claimed |