Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17780376 | 1.00 | ALK (0.35) | ALKRPS6KA3PTK2TNK2LRRK2 | |
| SCHEMBL17780575 | 0.94 | JAK2 (0.36) | ALKRPS6KA3PTK2TNK2LRRK2 | |
| SCHEMBL17780480 | 0.93 | PLK1 (0.39) | BRD4PLK1BRDTPARP1TAF1 | |
| SCHEMBL17780482 | 0.93 | PLK1 (0.39) | BRD4PLK1BRDTPARP1TAF1 | |
| SCHEMBL17780488 | 0.92 | PLK1 (0.35) | ALKRPS6KA3PTK2TNK2LRRK2 | |
| SCHEMBL17780449 | 0.91 | BRD4 (0.39) | LRRK2JAK2BRD4PLK1BRDT | |
| SCHEMBL17780427 | 0.89 | BRD4 (0.38) | ALKRPS6KA3PTK2TNK2LRRK2 | |
| SCHEMBL17780424 | 0.89 | BRD4 (0.38) | ALKRPS6KA3PTK2TNK2LRRK2 | |
| SCHEMBL17780532 | 0.88 | BRD4 (0.38) | LRRK2BRD4PLK1BRDTPARP1 | |
| SCHEMBL17780481 | 0.86 | CDK9 (0.41) | ALKRPS6KA3PTK2TNK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | claimed |