Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 15/20 | 0.39 |
| ▸ | BRD4 | O60885 | 14/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 10/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.35 |
| ▸ | TAF1 | P21675 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17780480 | 1.00 | PLK1 (0.39) | PLK1BRD4BRDTPARP1NUAK1 | |
| SCHEMBL17780427 | 0.94 | BRD4 (0.38) | PLK1BRD4BRDTPARP1NUAK1 | |
| SCHEMBL17780424 | 0.94 | BRD4 (0.38) | PLK1BRD4BRDTPARP1NUAK1 | |
| SCHEMBL17780532 | 0.93 | BRD4 (0.38) | PLK1BRD4BRDTPARP1TAF1 | |
| SCHEMBL17780376 | 0.93 | ALK (0.35) | PLK1BRD4BRDTPARP1TAF1 | |
| SCHEMBL17780372 | 0.93 | ALK (0.35) | PLK1BRD4BRDTPARP1TAF1 | |
| SCHEMBL17780449 | 0.93 | BRD4 (0.39) | PLK1BRD4BRDTPARP1TAF1 | |
| SCHEMBL17780456 | 0.92 | PLK1 (0.38) | PLK1BRD4BRDTPARP1NUAK1 | |
| SCHEMBL17780481 | 0.88 | CDK9 (0.41) | PLK1BRD4BRDTNUAK1TAF1 | |
| SCHEMBL17780478 | 0.88 | CDK9 (0.41) | PLK1BRD4BRDTNUAK1TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | claimed |