Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | MGAM | O43451 | 2/20 | 0.59 |
| ▸ | SI | P14410 | 2/20 | 0.59 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.59 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | SCD | O00767 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719399 | 0.78 | GAA (0.51) | GAAMGAMSIMGAM2GUSB | |
| SCHEMBL24075328 | 0.77 | KDM4E (0.62) | GAAMGAMSIMGAM2GUSB | |
| SCHEMBL4122566 | 0.75 | NPC1 (0.68) | GAAMGAMSIMGAM2KDM4E | |
| SCHEMBL700482 | 0.75 | GAA (0.51) | GAAMGAMSIMGAM2GUSB | |
| SCHEMBL26597187 | 0.73 | MMP13 (0.62) | GAAMGAMSIMGAM2SCD | |
| SCHEMBL30104615 | 0.70 | ALDH1A1 (0.68) | GAAMGAMSIMGAM2SCD | |
| SCHEMBL3333857 | 0.70 | ALDH1A1 (0.54) | GAAMGAMSIMGAM2GUSB | |
| SCHEMBL7270897 | 0.70 | CYP11B1 (0.58) | GAAMGAMSIMGAM2GUSB | |
| SCHEMBL31289464 | 0.70 | MEN1 (0.61) | GAAMGAMSIMGAM2GUSB | |
| SCHEMBL698248 | 0.70 | MGAM (0.56) | GAAMGAMSIMGAM2GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202370-B2 | Benzimidazole derivatives as selective proteine kinase inhibitors | AB SCIENCE (FR) | 2019-02-12 | — | — | US | disclosed |
| US-20160152608-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS | AB SCIENCE (FR) | 2016-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202370-B2 | Benzimidazole derivatives as selective proteine kinase inhibitors | KIT, CHUK, CSNK1E | GAA 1013/4885MGAM 3422/4885SI 2371/4885 |
| US-20160152608-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS | KIT, CHUK, CSNK1E | GAA 1013/4885MGAM 3422/4885SI 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.