Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778295 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1KMT2ACYP2D6 | |
| SCHEMBL6735770 | 0.91 | KMT2A (0.53) | ALDH1A1KDM4EMEN1KMT2ACYP2D6 | |
| SCHEMBL29512666 | 0.84 | SIGMAR1 (0.52) | KDM4EMEN1KMT2AADORA1SIGMAR1 | |
| SCHEMBL3129485 | 0.83 | SIGMAR1 (0.47) | ALDH1A1KDM4EMEN1KMT2ACYP2D6 | |
| SCHEMBL3129489 | 0.83 | SIGMAR1 (0.47) | ALDH1A1KDM4EMEN1KMT2ACYP2D6 | |
| SCHEMBL13355700 | 0.80 | SIGMAR1 (0.47) | MEN1KMT2ACYP2D6SIGMAR1ACHE | |
| SCHEMBL6745218 | 0.77 | SIGMAR1 (0.61) | ALDH1A1MEN1KMT2ACYP2D6SIGMAR1 | |
| SCHEMBL15962261 | 0.77 | SIGMAR1 (0.61) | KDM4EMEN1KMT2ACYP2D6SIGMAR1 | |
| SCHEMBL3824788 | 0.77 | MEN1 (0.55) | ALDH1A1MEN1KMT2ACYP2D6SIGMAR1 | |
| SCHEMBL2448897 | 0.76 | MEN1 (0.54) | ALDH1A1KDM4EMEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943605-B2 | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses | UCB PHARMA S.A. (BE) | 2011-05-17 | — | — | US | disclosed |