Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17784730 | 0.94 | MAPT (0.38) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17784701 | 0.93 | SLC6A4 (0.36) | DRD2SLC6A4HTR2AKCNH2IDO1 | |
| SCHEMBL9452824 | 0.81 | DRD2 (0.41) | DRD2NPC1RAB9ACA12CA1 | |
| SCHEMBL2880034 | 0.81 | MEN1 (0.36) | DRD2SLC6A4HTR2AKCNH2 | |
| SCHEMBL17786208 | 0.78 | PTGDR2 (0.39) | MAPTDRD2NPC1RAB9ACA12 | |
| SCHEMBL7565321 | 0.78 | DRD2 (0.35) | MAPTDRD2SMN1; SMN2CA12CA1 | |
| SCHEMBL17786198 | 0.77 | IDO1 (0.34) | DRD2SLC6A4HTR2AKCNH2IDO1 | |
| SCHEMBL17786202 | 0.76 | DRD2 (0.36) | MAPTDRD2SLC6A4HPGDSMN1; SMN2 | |
| SCHEMBL17184765 | 0.76 | APLNR (0.36) | DRD2SLC6A4HTR2AKCNH2CA12 | |
| SCHEMBL2882184 | 0.75 | IDO1 (0.35) | DRD2SLC6A4HTR2AKCNH2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224241-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Real Estate AB (SE) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016085391-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Life Science AB (SE) | 2016-06-02 | — | — | WO | disclosed |