Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.49 |
| ▸ | WNT1 | P04628 | 5/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17785617 | 0.95 | CYP11B2 (0.49) | CYP11B2USP30WNT1GSK3BDYRK1A | |
| SCHEMBL28481721 | 0.93 | CREBBP (0.50) | CYP11B2USP30WNT1GSK3BDYRK1A | |
| SCHEMBL17795310 | 0.84 | CYP11B2 (0.49) | CYP11B2USP30WNT1GSK3BDYRK1A | |
| SCHEMBL17809502 | 0.82 | CREBBP (0.44) | CYP11B2USP30WNT1GSK3BDYRK1A | |
| SCHEMBL17795412 | 0.80 | CYP11B2 (0.44) | CYP11B2USP30WNT1GSK3BDYRK1A | |
| SCHEMBL17785666 | 0.78 | CREBBP (0.48) | CYP11B2WNT1GSK3BDYRK1ACREBBP | |
| SCHEMBL17806203 | 0.78 | CREBBP (0.44) | CYP11B2USP30WNT1GSK3BDYRK1A | |
| SCHEMBL17809572 | 0.77 | CREBBP (0.50) | CREBBPBRD4 | |
| SCHEMBL17809627 | 0.77 | CREBBP (0.42) | CYP11B2USP30WNT1GSK3BDYRK1A | |
| SCHEMBL21255167 | 0.74 | HTR2A (0.40) | CYP11B2USP30WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224258-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | Genentech, Inc. (US) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016086200-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-02 | — | — | WO | disclosed |