Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 6/20 | 0.40 |
| ▸ | WNT1 | P04628 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21254819 | 0.82 | CREBBP (0.43) | CREBBPWNT1GSK3BDYRK1ACYP11B2 | |
| SCHEMBL19368731 | 0.81 | WNT1 (0.41) | HTR2AHTR2CHTR2BCREBBPWNT1 | |
| SCHEMBL17806203 | 0.79 | CREBBP (0.44) | CREBBPWNT1GSK3BDYRK1ACYP11B2 | |
| SCHEMBL17809502 | 0.78 | CREBBP (0.44) | CREBBPWNT1GSK3BDYRK1ACYP11B2 | |
| SCHEMBL17785752 | 0.74 | CYP11B2 (0.55) | CREBBPWNT1GSK3BDYRK1ACYP11B2 | |
| SCHEMBL17806250 | 0.74 | CREBBP (0.49) | CREBBPBRD4 | |
| SCHEMBL17806213 | 0.74 | CREBBP (0.41) | CREBBPWNT1GSK3BDYRK1AUSP30 | |
| SCHEMBL21254794 | 0.74 | CREBBP (0.45) | CREBBPBRD4 | |
| SCHEMBL19368744 | 0.74 | CREBBP (0.56) | CREBBPBRD4 | |
| SCHEMBL17809572 | 0.73 | CREBBP (0.50) | CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224258-B1 | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH INC (US) | 2019-08-14 | — | — | EP | disclosed |