Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 9/20 | 0.39 |
| ▸ | GSR | P00390 | 2/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL27571264 | 0.90 | BHMT (0.40) | BHMTGSRGRM8GRM6GRIN2D | |
| Glutamic Acid SCHEMBL17786011 | 0.90 | BHMT (0.35) | BHMTGSRGRM8GRM6GRIN2D | |
| Racemethionine SCHEMBL15323591 | 0.88 | GSR (0.45) | BHMTGSRGRM8GRM6GRIN2D | |
| Methionine SCHEMBL15323594 | 0.88 | GSR (0.45) | BHMTGSRGRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL27591999 | 0.85 | CYP1A2 (0.53) | BHMTGSRGRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL27672562 | 0.85 | CYP1A2 (0.53) | BHMTGSRGRM8GRM6GRIN2D | |
| Glutamic Acid SCHEMBL8426545 | 0.85 | GRM8 (0.53) | BHMTGSRGRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL27658668 | 0.84 | GSR (0.54) | BHMTGSRGRM8GRM6GRIN2D | |
| D-Glutamate SCHEMBL27695586 | 0.84 | CYP1A2 (0.49) | BHMTGSRGRM8GRM6GRIN2D | |
| Racemethionine SCHEMBL15322970 | 0.84 | GSR (0.49) | BHMTGSRBHMT2CYP2C19THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083399-A9 | ALPHA-KETOGLUTARATE IN COMBINATION WITH GLUTAMATE DEHYDROGENASE FOR TREATING HYPERAMMONEMIA | FORSCHUNGSGESELLSCHAFT FÜR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E. V. (DE) | 2016-12-22 | — | — | WO | disclosed |
| WO-2016083399-A1 | ALPHA-KETOGLUTARATE IN COMBINATION WITH GLUTAMATE DEHYDROGENASE FOR TREATING HYPERAMMONEMIA | FORSCHUNGSGESELLSCHAFT FÜR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E. V. (DE) | 2016-06-02 | — | — | WO | disclosed |