Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Racemethionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.45 |
| ▸ | BHMT | Q93088 | 12/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methionine SCHEMBL15323594 | 1.00 | GSR (0.45) | GSRBHMTGRM8GRM6GRIN2D | |
| Methionine SCHEMBL15322975 | 0.93 | GSR (0.49) | GSRBHMTBHMT2CYP2C19THPO | |
| Racemethionine SCHEMBL15322970 | 0.93 | GSR (0.49) | GSRBHMTBHMT2CYP2C19THPO | |
| Lysine SCHEMBL8679695 | 0.91 | GSR (0.57) | GSRBHMTCYP1A2BHMT2CYP2C19 | |
| Lysine SCHEMBL8679690 | 0.91 | GSR (0.57) | GSRBHMTCYP1A2BHMT2CYP2C19 | |
| Lysine SCHEMBL16876651 | 0.90 | GSR (0.53) | GSRBHMTCYP1A2BHMT2CYP2C19 | |
| Lysine SCHEMBL16876653 | 0.90 | GSR (0.53) | GSRBHMTCYP1A2BHMT2CYP2C19 | |
| D-Glutamate SCHEMBL17786010 | 0.88 | BHMT (0.39) | GSRBHMTGRM8GRM6GRIN2D | |
| Ornithine SCHEMBL15322972 | 0.86 | GSR (0.42) | GSRBHMTBHMT2CYP2C19THPO | |
| Racemethionine SCHEMBL4361129 | 0.86 | BHMT (0.46) | GSRBHMTGRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836832-A1 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155458-A1 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |