Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.35 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786201 | 0.87 | IDO1 (0.39) | IDO1HTR2ASLC6A4KCNH2CYP2C19 | |
| SCHEMBL17786197 | 0.84 | IDO1 (0.40) | IDO1HTR2ASLC6A4KCNH2CYP2C19 | |
| SCHEMBL17786198 | 0.82 | IDO1 (0.34) | IDO1HTR2ASLC6A4KCNH2HSD17B10 | |
| SCHEMBL7565321 | 0.80 | DRD2 (0.35) | USP2ALDH1A1HSD17B10KLF10PPARA | |
| SCHEMBL17786208 | 0.80 | PTGDR2 (0.39) | ALDH1A1NPC1RAB9APTGDR2 | |
| SCHEMBL17784730 | 0.79 | MAPT (0.38) | IDO1HTR2ASLC6A4KCNH2ALDH1A1 | |
| SCHEMBL6498758 | 0.78 | PDCD1 (0.46) | IDO1HTR2ASLC6A4KCNH2CYP2C19 | |
| SCHEMBL31321848 | 0.78 | PDCD1 (0.46) | IDO1HTR2ASLC6A4KCNH2CYP2C19 | |
| SCHEMBL908935 | 0.77 | NR1H2 (0.37) | IDO1CYP2C19KDM4EUSP2ALDH1A1 | |
| SCHEMBL13746429 | 0.76 | CA12 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107001309-B | Bis (sulfonamide) derivatives and their use as MPGES inhibitors | 格辛塔制药公司 | 2021-03-05 | — | — | CN | disclosed |
| EP-3224253-B1 | BIS (SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | GESYNTA PHARMA AB (SE) | 2019-10-30 | — | — | EP | disclosed |
| US-10081614-B2 | Bis(sulfonamide) derivatives and their use as mPGES inhibitors | ACTURUM REAL ESTATE AB (SE) | 2018-09-25 | — | — | US | disclosed |
| US-20170313672-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | GESYNTA PHARMA AB (SE) | 2017-11-02 | — | — | US | disclosed |
| US-20170313672-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | GESYNTA PHARMA AB (SE) | 2017-11-02 | — | — | US | disclosed |
| US-20170313672-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | GESYNTA PHARMA AB (SE) | 2017-11-02 | — | — | US | disclosed |
| EP-3224253-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Real Estate AB (SE) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016085392-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | Acturum Life Science AB (SE) | 2016-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10081614-B2 | Bis(sulfonamide) derivatives and their use as mPGES inhibitors | PTGES, PTGS1, PTGES2 | IDO1 857/4885HTR2A 666/4885SLC6A4 1882/4885 |
| US-20170313672-A1 | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | PTGES, PTGS1, PTGES2 | IDO1 857/4885HTR2A 666/4885SLC6A4 1882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.