SCHEMBL17786264

SCHEMBL17786264

CC(C)CCn1c(CN2CCCN(C(=O)C3CC3)CC2)nc2c1c(=O)n(C)c(=O)n2C

nearest known ligand 0.93

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 14/20 0.93
KMT2A Q03164 2/20 0.68
MEN1 O00255 1/20 0.62
HSD17B10 Q99714 3/20 0.61
USP2 O75604 2/20 0.61
HTT P42858 2/20 0.61
TSHR P16473 4/20 0.61
NPSR1 Q6W5P4 2/20 0.61
GAA P10253 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
TP53 P04637 1/20 0.55
LMNA P02545 1/20 0.53
RXFP1 Q9HBX9 1/20 0.51
PKM P14618 1/20 0.50
RECQL P46063 2/20 0.49
POLB P06746 1/20 0.49
KDM4E B2RXH2 1/20 0.49
MAPT P10636 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17786253 0.96 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1HSD17B10USP2
Hydrochloric Acid SCHEMBL30362049 0.95 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1HSD17B10USP2
SCHEMBL17791579 0.91 ALDH1A1 (0.89) ALDH1A1KMT2AMEN1HSD17B10USP2
SCHEMBL17791583 0.84 ALDH1A1 (0.81) ALDH1A1KMT2AMEN1HSD17B10USP2
SCHEMBL17791540 0.82 ALDH1A1 (0.72) ALDH1A1KMT2AHSD17B10HTTTSHR
SCHEMBL17207512 0.82 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1HSD17B10USP2
SCHEMBL17786233 0.81 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1HSD17B10USP2
SCHEMBL17786260 0.80 ALDH1A1 (0.75) ALDH1A1KMT2AMEN1HSD17B10USP2
SCHEMBL17791573 0.80 ALDH1A1 (0.75) ALDH1A1KMT2AMEN1HSD17B10USP2
SCHEMBL17207523 0.80 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1HSD17B10USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016086008-A1 SMALL MOLECULE ALDEHYDE DEHYDROGENASE INHIBITORS AND METHODS OF USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-06-02 WO disclosed
WO-2016086008-A1 SMALL MOLECULE ALDEHYDE DEHYDROGENASE INHIBITORS AND METHODS OF USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-06-02 WO disclosed