Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL925773 | 0.89 | MAPT (0.79) | EGFRSRCMAPTKDM4ETP53 | |
| SCHEMBL7079959 | 0.88 | KDM4E (0.73) | EGFRSRCMAPTKDM4ETP53 | |
| SCHEMBL17786635 | 0.85 | EGFR (0.62) | EGFRSRCMAPTKDM4ETP53 | |
| SCHEMBL17786403 | 0.84 | CSNK2A2 (0.73) | EGFRSRCMAPTKDM4ETP53 | |
| SCHEMBL4983269 | 0.83 | MAPT (0.84) | EGFRSRCMAPTKDM4ETP53 | |
| 3',5'-Dimethoxyflavone SCHEMBL29149133 | 0.81 | TNKS (0.78) | MAPTKDM4ETP53CYP3A4NPC1 | |
| SCHEMBL17786381 | 0.81 | FYN (0.73) | EGFRSRCMAPTKDM4ETP53 | |
| 6-Aminoflavone SCHEMBL31550004 | 0.78 | EGFR (0.82) | EGFRSRCMAPTKDM4ETP53 | |
| 6-Aminoflavone SCHEMBL926716 | 0.78 | EGFR (0.82) | EGFRSRCMAPTKDM4ETP53 | |
| SCHEMBL31364277 | 0.78 | MAOB (0.81) | MAPTKDM4ETP53CYP3A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083490-A1 | COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES | REMYND NV (BE) | 2016-06-02 | — | — | WO | disclosed |