Sugi Predict

Sugi Predict / Compounds / SCHEMBL1778745

SCHEMBL1778745

SCHEMBL1778745

CCOC(=O)n1nc(NC(=O)c2ccccc2NC(=O)c2ccc[nH]2)c2cc(C(=O)NC(C)(C)c3ccccc3F)sc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 4/20 0.35
▸ KDM4E B2RXH2 3/20 0.35
▸ ALDH1A1 P00352 3/20 0.35
▸ GAA P10253 3/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ MAPK1 P28482 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ MAPT P10636 6/20 0.34
▸ PPARG P37231 1/20 0.34
▸ NR1H4 Q96RI1 1/20 0.34
▸ TP53 P04637 4/20 0.34
▸ SMN1; SMN2 Q16637 3/20 0.34
▸ NPC1 O15118 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ LMNA P02545 1/20 0.33
▸ TSHR P16473 2/20 0.33
▸ HPGD P15428 1/20 0.33
▸ NPSR1 Q6W5P4 2/20 0.33
▸ CREBBP Q92793 1/20 0.33
▸ RXFP1 Q9HBX9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1778679 0.91 MAPT (0.37) HSD17B10KDM4EALDH1A1GAAMAPT
SCHEMBL1779011 0.89 IGF1R (0.43) HSD17B10KDM4EALDH1A1GAAKMT2A
SCHEMBL1778410 0.87 ALDH1A1 (0.40) HSD17B10KDM4EALDH1A1GAAKMT2A
SCHEMBL1777881 0.87 HSD17B10 (0.35) HSD17B10KDM4EALDH1A1GAAKMT2A
SCHEMBL1780035 0.87 KMT2A (0.38) HSD17B10KDM4EALDH1A1GAAKMT2A
SCHEMBL1778607 0.86 ALDH1A1 (0.38) HSD17B10KDM4EALDH1A1GAAKMT2A
SCHEMBL1779872 0.86 KDR (0.37) HSD17B10KDM4EALDH1A1GAAKMT2A
SCHEMBL1778268 0.86 ALDH1A1 (0.39) HSD17B10KDM4EALDH1A1GAAKMT2A
SCHEMBL15372478 0.86 HSD17B10 (0.37) HSD17B10KDM4EALDH1A1GAAKMT2A
SCHEMBL1780516 0.85 KDM4E (0.38) HSD17B10KDM4EALDH1A1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904503-B1 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2013-11-06 — — EP disclosed
US-7943654-B2 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-17 — — US disclosed
US-20090149457-A1 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-06-11 — — US disclosed
EP-1904503-A1 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.r.l. (IT) 2008-04-02 — — EP disclosed
WO-2007009898-A1 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-01-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090149457-A1 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors CCNH, PDK1, MAP3K5 HSD17B10 2498/4885KDM4E 2856/4885ALDH1A1 3557/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.