SCHEMBL17787705

SCHEMBL17787705

O=C(NC12CC3CC(C1)NC(C3)C2)OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 7/20 0.52
FAAH O00519 4/20 0.51
CNR2 P34972 3/20 0.51
CNR1 P21554 1/20 0.51
FKBP1A P62942 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
ALDH1A1 P00352 1/20 0.50
MAPK1 P28482 1/20 0.50
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
EPHX1 P07099 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13575194 0.82 EPHX2 (0.52) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL1497415 0.82 EPHX2 (0.54) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL1556682 0.82 EPHX2 (0.52) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL13575195 0.82 EPHX2 (0.52) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL16665110 0.82 EPHX2 (0.53) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL1497428 0.81 EPHX2 (0.51) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL1497397 0.81 FAAH (0.53) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL10297219 0.81 EPHX2 (0.51) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL974457 0.81 EPHX2 (0.51) EPHX2FAAHCNR2CNR1FKBP1A
SCHEMBL973910 0.81 EPHX2 (0.51) EPHX2FAAHCNR2CNR1FKBP1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2507225-B1 L -DIHYDRO-2-OXOQUINOLINE COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS SUVEN LIFE SCIENCES LTD (IN) 2016-06-01 EP disclosed