⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899174 | 0.81 | — | — | |
| SCHEMBL17270 | 0.78 | LTA4H (0.38) | — | |
| Hydrochloric Acid SCHEMBL16709 | 0.77 | LTA4H (0.38) | — | |
| SCHEMBL17910 | 0.71 | — | — | |
| SCHEMBL18930 | 0.71 | GCK (0.43) | — | |
| SCHEMBL19663 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL17450 | 0.68 | — | — | |
| SCHEMBL14899163 | 0.65 | HRH3 (0.30) | — | |
| SCHEMBL18028 | 0.62 | CHRM2 (0.41) | — | |
| SCHEMBL12093536 | 0.62 | SMN1; SMN2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431563-B2 | Compounds that interact with glucokinase regulatory protein for the treatment of diabetes | AMGEN INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120225854-A1 | COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-09-06 | — | — | US | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |