⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17450 | 0.98 | — | — | |
| SCHEMBL30232798 | 0.71 | CHRM2 (0.43) | — | |
| SCHEMBL17872 | 0.68 | ADRB1 (0.32) | — | |
| SCHEMBL28982691 | 0.68 | GAA (0.38) | — | |
| SCHEMBL5892038 | 0.67 | CXCR4 (0.41) | — | |
| Hydrochloric Acid SCHEMBL6788921 | 0.67 | GAA (0.37) | — | |
| SCHEMBL16723 | 0.65 | LTA4H (0.33) | — | |
| SCHEMBL10418359 | 0.64 | CXCR4 (0.46) | — | |
| SCHEMBL8658731 | 0.64 | CXCR4 (0.50) | — | |
| SCHEMBL336761 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431563-B2 | Compounds that interact with glucokinase regulatory protein for the treatment of diabetes | AMGEN INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120225854-A1 | COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-09-06 | — | — | US | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |