Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.49 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.49 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.49 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.49 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.49 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17792558 | 0.78 | KDM4E (0.40) | CYP1A2CYP2C9CYP2C19KMT2AMAPT | |
| SCHEMBL20272577 | 0.69 | CYP1A2 (0.59) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL17792496 | 0.68 | NPSR1 (0.33) | CYP1A2CYP2C9CYP2C19KMT2AMAPT | |
| SCHEMBL17792562 | 0.67 | CYP1A2 (0.34) | CYP1A2MEN1CYP2C9CYP2C19KMT2A | |
| (R,S)-Ampa SCHEMBL6687427 | 0.66 | GRIA1 (1.00) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL19195013 | 0.66 | KDM4E (0.47) | CYP1A2KMT2AMAPTALDH1A1TSHR | |
| (R,S)-Ampa SCHEMBL13957590 | 0.66 | GRIA1 (1.00) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL19194554 | 0.66 | EZH2 (0.54) | — | |
| SCHEMBL14591562 | 0.66 | P2RX7 (0.52) | MEN1KMT2A | |
| SCHEMBL17792537 | 0.65 | EZH2 (0.35) | CYP1A2CYP2C9CYP2C19KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624205-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-04-18 | — | — | US | disclosed |
| US-20160152604-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. | 2016-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152604-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP3A5, PAICS | GRIA1 3797/4885GRIA3 2699/4885GRIA4 3449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.