Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742901 | 0.94 | ABL1 (0.49) | ABL1BCRAURKAEGLN1ROCK1 | |
| SCHEMBL3865998 | 0.88 | ROCK1 (0.41) | ROCK1NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL1778129 | 0.87 | AURKA (0.43) | ABL1BCRAURKANPC1RAB9A | |
| SCHEMBL1779700 | 0.86 | AURKA (0.50) | ABL1BCRAURKANPC1RAB9A | |
| SCHEMBL1777885 | 0.86 | AURKA (0.46) | ABL1BCRAURKAEGLN1RAB9A | |
| SCHEMBL1778032 | 0.86 | AURKA (0.42) | ABL1BCRAURKAPPARGNR1H4 | |
| SCHEMBL1779328 | 0.86 | RXFP1 (0.44) | ABL1BCRAURKASMN1; SMN2L3MBTL1 | |
| SCHEMBL1780795 | 0.85 | AURKA (0.45) | ABL1BCRAURKAPPARGNR1H4 | |
| SCHEMBL1779223 | 0.85 | AURKA (0.43) | ABL1BCRAURKAEGLN1ROCK1 | |
| SCHEMBL1778864 | 0.85 | AURKA (0.41) | ABL1BCRAURKAEGLN1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |