Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.44 |
| ▸ | PPARG | P37231 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780912 | 0.95 | AURKA (0.49) | AURKAABL1BCRNR1H4PPARG | |
| SCHEMBL1778008 | 0.94 | AURKA (0.49) | AURKAABL1BCRNR1H4PPARG | |
| SCHEMBL740292 | 0.93 | AURKA (0.55) | AURKAABL1BCRRXFP1NPC1 | |
| SCHEMBL1779927 | 0.92 | RXFP1 (0.49) | AURKAABL1BCRNR1H4PPARG | |
| SCHEMBL1779328 | 0.92 | RXFP1 (0.44) | AURKAABL1BCRNR1H4PPARG | |
| SCHEMBL1780795 | 0.92 | AURKA (0.45) | AURKAABL1BCRNR1H4PPARG | |
| SCHEMBL1780794 | 0.91 | AURKA (0.46) | AURKAABL1BCRNR1H4PPARG | |
| SCHEMBL1778872 | 0.91 | AURKA (0.46) | AURKAABL1BCRNR1H4PPARG | |
| SCHEMBL1778129 | 0.91 | AURKA (0.43) | AURKAABL1BCRNR1H4PPARG | |
| SCHEMBL1779492 | 0.91 | AURKA (0.44) | AURKAABL1BCRNR1H4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |