Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872706 | 0.87 | KCNMA1 (0.38) | ALDH1A1KMT2ALMNAKDM4EHSD17B10 | |
| SCHEMBL1778344 | 0.83 | AURKA (0.43) | BDKRB1AURKAKDM4E | |
| SCHEMBL1778920 | 0.83 | KDR (0.46) | ALDH1A1KMT2ALMNAAURKAKDM4E | |
| SCHEMBL1780165 | 0.82 | FGFR4 (0.37) | KDM4EMAPK1 | |
| SCHEMBL14639983 | 0.82 | PPARG (0.36) | BDKRB1AURKAKDM4E | |
| SCHEMBL15372479 | 0.80 | HSD17B13 (0.38) | KDM4E | |
| SCHEMBL1779132 | 0.79 | NR1H4 (0.37) | AURKAMAPK1 | |
| SCHEMBL14639984 | 0.78 | PPARG (0.36) | BDKRB1MAPK1 | |
| SCHEMBL3866786 | 0.78 | KDM4E (0.48) | ALDH1A1KMT2AKDM4EHDAC6MAPT | |
| SCHEMBL3866838 | 0.77 | CYP1A2 (0.42) | KMT2ABDKRB1KDM4EMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |