Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.60 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.51 |
| ▸ | DHODH | Q02127 | 2/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30283775 | 0.87 | ERN1 (0.60) | ERN1HSD17B1HSD17B2PDK2LMNA | |
| SCHEMBL1135975 | 0.87 | ERN1 (0.60) | ERN1HSD17B1HSD17B2PDK2LMNA | |
| SCHEMBL18311613 | 0.86 | ERN1 (0.64) | ERN1HSD17B1HSD17B2PDK2LMNA | |
| Hydrochloric Acid SCHEMBL28646857 | 0.86 | ERN1 (0.59) | ERN1HSD17B1HSD17B2PDK2LMNA | |
| SCHEMBL12168605 | 0.85 | ERN1 (0.58) | ERN1PDK2LMNAHDAC6KMO | |
| SCHEMBL13680496 | 0.83 | HSD17B2 (0.72) | ERN1HSD17B1HSD17B2PDK2LMNA | |
| SCHEMBL20057645 | 0.82 | HPGD (0.72) | ERN1HSD17B2LMNAHPGDTSHR | |
| SCHEMBL19567237 | 0.82 | ERN1 (0.56) | ERN1HSD17B1HSD17B2PDK2LMNA | |
| SCHEMBL19369002 | 0.82 | ERN1 (0.56) | ERN1HSD17B1HSD17B2PDK2LMNA | |
| SCHEMBL17806554 | 0.82 | ERN1 (0.56) | ERN1HSD17B1HSD17B2DHODHPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224258-B1 | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH INC (US) | 2019-08-14 | — | — | EP | disclosed |
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016086200-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-02 | — | — | WO | disclosed |