Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 4/20 | 0.72 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.72 |
| ▸ | ERN1 | O75460 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18317091 | 0.83 | HSD17B1 (0.67) | HSD17B2HSD17B1ERN1CYP3A4CYP2C9 | |
| SCHEMBL17795214 | 0.83 | ERN1 (0.60) | HSD17B2HSD17B1ERN1CYP3A4HPGD | |
| SCHEMBL24061101 | 0.82 | HSD17B2 (0.63) | HSD17B2HSD17B1ALDH1A1HPGDMAPT | |
| SCHEMBL8364545 | 0.81 | ERN1 (0.51) | HSD17B2HSD17B1ERN1CYP1A2CYP3A4 | |
| SCHEMBL24732320 | 0.81 | HSD17B2 (0.59) | HSD17B2HSD17B1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2047793 | 0.81 | HPGD (0.63) | ERN1CYP1A2CYP3A4ALDH1A1HPGD | |
| SCHEMBL16574187 | 0.81 | ALDH1A1 (0.55) | HSD17B2HSD17B1ERN1CYP1A2CYP3A4 | |
| SCHEMBL10626283 | 0.81 | ALDH1A1 (0.64) | ERN1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL4428711 | 0.80 | MAPT (0.64) | HSD17B2HSD17B1ALDH1A1HPGDKDM4E | |
| SCHEMBL2610268 | 0.80 | RXRA (0.69) | HSD17B2HSD17B1ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3865472-A1 | THROMBOXANE RECEPTOR ANTAGONISTS | ATXA Therapeutics Limited (IE) | 2021-08-18 | — | — | EP | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |