Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.39 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27316556 | 0.83 | LRRK2 (0.47) | LRRK2BRD4RIPK2BTKSMARCA2 | |
| SCHEMBL17809683 | 0.83 | LRRK2 (0.54) | LRRK2BRD4RIPK2BTKSMARCA2 | |
| SCHEMBL17785770 | 0.80 | AXL (0.51) | LRRK2BRD4RIPK2BTKSMARCA2 | |
| SCHEMBL10094634 | 0.80 | LRRK2 (0.48) | LRRK2BRD4RIPK2BTKPIK3CG | |
| SCHEMBL24731507 | 0.79 | LMNA (0.50) | LRRK2BRD4RIPK2BTKSMARCA2 | |
| SCHEMBL17806497 | 0.78 | PIK3CG (0.43) | LRRK2BRD4RIPK2BTKSMARCA2 | |
| SCHEMBL20961827 | 0.77 | LRRK2 (0.46) | LRRK2BRD4RIPK2SMARCA2SMARCA4 | |
| SCHEMBL17489511 | 0.76 | FLT3 (0.46) | LRRK2 | |
| SCHEMBL24992450 | 0.76 | ROCK2 (0.42) | LRRK2BRD4 | |
| SCHEMBL10094625 | 0.75 | BRD4 (0.54) | LRRK2BRD4BTKSMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016086200-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-02 | — | — | WO | disclosed |