Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17792394 | 0.89 | PKM (0.56) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16401866 | 0.89 | PLA2G2A (0.67) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16400838 | 0.86 | PLA2G2A (0.60) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16401883 | 0.83 | PLA2G2A (0.48) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16401294 | 0.83 | PLA2G2A (0.48) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30572427 | 0.82 | MEN1 (0.71) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16401074 | 0.82 | MEN1 (0.71) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17796016 | 0.81 | KDM4E (0.42) | PLA2G2AALDH1A1L3MBTL1PKMMAPT | |
| SCHEMBL10091835 | 0.80 | CA12 (0.49) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6289446 | 0.75 | KMT2A (0.47) | PLA2G2AMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160152612-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152612-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | PDE5A, PDE2A, PDE3A | PLA2G2A 718/4885MEN1 3763/4885KMT2A 1442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.