Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777881 | 0.91 | HSD17B10 (0.35) | RXFP1MAPTRAB9ANPC1CSF1R | |
| SCHEMBL1779174 | 0.89 | RAB9A (0.39) | RXFP1MAPTRAB9ANPC1CSF1R | |
| SCHEMBL1780828 | 0.88 | AURKA (0.45) | ABL1BCRAURKACSF1R | |
| SCHEMBL1780244 | 0.88 | HSD17B10 (0.38) | RXFP1MAPTRAB9ANPC1CSF1R | |
| SCHEMBL1778509 | 0.87 | RXFP1 (0.41) | RXFP1MAPTRAB9ANPC1KDM4E | |
| SCHEMBL1778679 | 0.86 | MAPT (0.37) | RXFP1ABL1BCRMAPTAURKA | |
| SCHEMBL1779428 | 0.85 | ABL1 (0.40) | RXFP1ABL1BCRMAPTAURKA | |
| SCHEMBL1433343 | 0.85 | ABL1 (0.39) | RXFP1ABL1BCRMAPTAURKA | |
| SCHEMBL1781304 | 0.85 | KDR (0.37) | RXFP1ABL1BCRMAPTRAB9A | |
| SCHEMBL1433182 | 0.84 | RXFP1 (0.38) | RXFP1ABL1BCRMAPTAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904503-B1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-11-06 | — | — | EP | disclosed |
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |
| US-20090149457-A1 | 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149457-A1 | 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors | CCNH, PDK1, MAP3K5 | RXFP1 3180/4885ABL1 397/4885BCR 1047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.