Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 10/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 13/20 | 0.45 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779700 | 0.95 | AURKA (0.50) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL1778008 | 0.92 | AURKA (0.49) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL1779927 | 0.91 | RXFP1 (0.49) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL1779328 | 0.90 | RXFP1 (0.44) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL1779104 | 0.89 | AURKA (0.43) | AURKAABL1BCRPPARGNR1H4 | |
| SCHEMBL1780795 | 0.88 | AURKA (0.45) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL1780794 | 0.88 | AURKA (0.46) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL1778872 | 0.88 | AURKA (0.46) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL740292 | 0.88 | AURKA (0.55) | AURKAABL1BCRRXFP1 | |
| SCHEMBL1780888 | 0.88 | RXFP1 (0.46) | AURKAABL1BCRRXFP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |