Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 10/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17797552 | 0.96 | TMEM97 (0.55) | TMEM97SIGMAR1NPC1RAB9AESR2 | |
| SCHEMBL2181843 | 0.94 | ESR2 (0.58) | TMEM97SIGMAR1NPC1RAB9AESR2 | |
| SCHEMBL17801727 | 0.85 | TMEM97 (0.56) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL4930098 | 0.85 | CTSL (0.47) | TMEM97SIGMAR1NPC1RAB9AESR2 | |
| SCHEMBL30981194 | 0.85 | NPC1 (0.46) | TMEM97SIGMAR1NPC1RAB9AESR2 | |
| Iodide SCHEMBL4639203 | 0.84 | TMEM97 (0.44) | TMEM97SIGMAR1NPC1RAB9AESR2 | |
| SCHEMBL6292442 | 0.84 | TMEM97 (0.62) | TMEM97SIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL350596 | 0.84 | ESR2 (0.60) | TMEM97SIGMAR1NPC1RAB9AESR2 | |
| SCHEMBL17797565 | 0.83 | TMEM97 (0.54) | TMEM97SIGMAR1NPC1RAB9APSEN1 | |
| SCHEMBL3007640 | 0.83 | KDM1A (0.49) | ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159774-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE CAR LLC (BM) | 2016-06-09 | — | — | US | disclosed |
| WO-2016090079-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016090079-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159774-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | TMEM97 1731/4885SIGMAR1 545/4885NPC1 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.