SCHEMBL17799646

SCHEMBL17799646

O=C(N[C@H]1CC[C@H]1c1ccc(F)cc1F)c1ncccn1

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MC1R Q01726 9/20 0.45
▸ P2RX7 Q99572 3/20 0.40
▸ DHODH Q02127 1/20 0.40
▸ PDE4B Q07343 1/20 0.40
▸ GRM5 P41594 1/20 0.40
▸ HCRTR1 O43613 1/20 0.39
▸ FPR1 P21462 1/20 0.39
▸ FPR2 P25090 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17799730 0.87 HCRTR1 (0.53) MC1RP2RX7PDE4BHCRTR1
SCHEMBL17799664 0.84 MC1R (0.43) MC1RP2RX7PDE4BHCRTR1
SCHEMBL17799720 0.84 GRM5 (0.45) MC1RDHODHPDE4BGRM5HCRTR1
SCHEMBL17799638 0.84 HCRTR1 (0.54) MC1RP2RX7PDE4BHCRTR1
SCHEMBL17799632 0.84 EGFR (0.46) MC1RHCRTR1FPR1FPR2
SCHEMBL17799746 0.84 MC1R (0.45) MC1RP2RX7PDE4BHCRTR1FPR1
SCHEMBL17799700 0.83 HCRTR1 (0.49) MC1RGRM5HCRTR1FPR1FPR2
SCHEMBL19775167 0.83 HCRTR1 (0.46) MC1RP2RX7HCRTR1
SCHEMBL16371864 0.83 HCRTR1 (0.46) MC1RP2RX7HCRTR1
SCHEMBL19767311 0.82 HCRTR1 (0.43) MC1RP2RX7HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50724-E1 4-membered ring carboxamides used as nematicides SYNGENTA CROP PROTECTION AG (CH) 2026-01-06 — — US disclosed
EP-3019476-B1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-17 — — EP disclosed
US-9867371-B2 4-membered ring carboxamides used as nematicides SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 — — US disclosed
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2016-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES TUBA3C, DDT, CYCS MC1R 2554/4885P2RX7 666/4885DHODH 244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback