Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664600 | 0.64 | PDE4A (0.30) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29724735 | 0.58 | HTT (0.31) | — | |
| SCHEMBL31419892 | 0.57 | SMN1; SMN2 (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2117765 | 0.57 | SMN1; SMN2 (0.41) | PDE4APDE4BPDE4CPDE4D | |
| Potassium SCHEMBL29540173 | 0.57 | — | — | |
| SCHEMBL287569 | 0.55 | ALDH1A1 (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2128819 | 0.55 | — | — | |
| SCHEMBL6916146 | 0.55 | — | — | |
| SCHEMBL1350019 | 0.55 | — | — | |
| SCHEMBL41301 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160314-B | Heterocyclic aromatic amide compound and preparation method and application thereof | 南方医科大学 | 2023-12-05 | — | — | CN | disclosed |
| CN-115160314-A | Heterocyclic aromatic amide compound and preparation method and application thereof | 南方医科大学 | 2022-10-11 | — | — | CN | disclosed |
| CN-110372703-A | Five-ring heterocycles miazines compound and application thereof | 罗欣生物科技（上海）有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110177553-A | Alkyl Pyrrolopyrimidine is like object and its preparation and application | 北卡罗来纳大学教堂山分校 | 2019-08-27 | — | — | CN | disclosed |
| CN-110088096-A | Piperidine derivatives as inhibitors of ubiquitin-specific protease 7 | 阿尔麦克探索有限公司 | 2019-08-02 | — | — | CN | disclosed |
| EP-3227298-A1 | PROCESS FOR THE PREPARATION OF BARICITINIB AND AN INTERMEDIATE THEREOF | Sun Pharmaceutical Industries Ltd (IN) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016088094-A1 | PROCESS FOR THE PREPARATION OF BARICITINIB AND AN INTERMEDIATE THEREOF | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2016-06-09 | — | — | WO | disclosed |
| CN-104507923-A | Substituted pyrrole active agents as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2015-04-08 | — | — | CN | disclosed |
| CN-102348693-A | Methods for preparing JAK inhibitors and related intermediate compounds | INCYTE CORP | 2012-02-08 | — | — | CN | disclosed |