Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533024 | 0.84 | PDPK1 (0.73) | PDPK1FGFR1FLT1PKN2CHEK1 | |
| SCHEMBL5379078 | 0.80 | KDM4E (0.65) | PDPK1NPC1RAB9AGAAFGFR1 | |
| SCHEMBL29386825 | 0.78 | NPC1 (0.88) | NPC1RAB9AGAASMN1; SMN2KDM4E | |
| SCHEMBL2178266 | 0.78 | NPC1 (0.88) | NPC1RAB9AGAASMN1; SMN2KDM4E | |
| SCHEMBL18323218 | 0.77 | NPC1 (0.62) | NPC1RAB9AGAAFGFR1FLT1 | |
| SCHEMBL17801060 | 0.77 | PDPK1 (0.60) | PDPK1GAAFGFR1FLT1KDM4E | |
| SCHEMBL481735 | 0.77 | NPC1 (0.72) | NPC1RAB9AGAASMN1; SMN2KDM4E | |
| SCHEMBL5508118 | 0.77 | PDPK1 (0.74) | PDPK1NPC1RAB9AGAAFGFR1 | |
| SCHEMBL24295036 | 0.77 | NPC1 (0.84) | NPC1RAB9AGAASMN1; SMN2KDM4E | |
| SCHEMBL3532060 | 0.76 | CHEK1 (0.79) | PDPK1FGFR1FLT1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |