Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | CCND3 | P30281 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25418501 | 0.93 | PDPK1 (0.71) | PDPK1FGFR1FLT1ITKJAK2 | |
| SCHEMBL31472525 | 0.93 | PDPK1 (0.71) | PDPK1FGFR1FLT1ITKJAK2 | |
| SCHEMBL17801060 | 0.90 | PDPK1 (0.60) | PDPK1FGFR1FLT1ITKJAK2 | |
| SCHEMBL3338846 | 0.86 | KDM4E (0.61) | NPC1RAB9AKDM4EALDH1A1TP53 | |
| SCHEMBL5952338 | 0.84 | PDPK1 (0.59) | PDPK1FGFR1FLT1ITKJAK2 | |
| SCHEMBL1225637 | 0.83 | PDPK1 (0.67) | PDPK1FGFR1FLT1ITKJAK2 | |
| SCHEMBL3533024 | 0.83 | PDPK1 (0.73) | PDPK1FGFR1FLT1ITKJAK2 | |
| SCHEMBL17801025 | 0.81 | LRRK2 (0.50) | PDPK1ITKTDO2LRRK2ADORA2A | |
| SCHEMBL20982453 | 0.79 | RHEB (0.52) | NPC1RAB9AKDM4EALDH1A1TP53 | |
| SCHEMBL17696918 | 0.79 | AURKA (0.60) | ITKTDO2NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |