Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 7/20 | 0.71 |
| ▸ | CDK4 | P11802 | 3/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.58 |
| ▸ | CCND1 | P24385 | 3/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | CCND3 | P30281 | 3/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.58 |
| ▸ | TYK2 | P29597 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | ITK | Q08881 | 2/20 | 0.51 |
| ▸ | WNT1 | P04628 | 2/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK3 | P49761 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | MAP3K8 | P41279 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25418501 | 1.00 | PDPK1 (0.71) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL17801048 | 0.93 | PDPK1 (0.62) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL5952338 | 0.91 | PDPK1 (0.59) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL1225637 | 0.88 | PDPK1 (0.67) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL5508118 | 0.86 | PDPK1 (0.74) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL17801060 | 0.85 | PDPK1 (0.60) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL3533024 | 0.83 | PDPK1 (0.73) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL5510140 | 0.83 | CDK4 (0.83) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL3533531 | 0.81 | FGFR1 (0.66) | PDPK1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL5951956 | 0.81 | FGFR1 (0.66) | PDPK1CDK4CCNA2CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099442-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES INC | 2025-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250099442-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | DYRK2, DYRK1A, DYRK1B | PDPK1 61/4885CDK4 1402/4885CCNA2 2038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.