Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801582 | 0.85 | ATIC (0.46) | ATICTHRB | |
| SCHEMBL17808411 | 0.83 | ATIC (0.66) | ATICTHRB | |
| SCHEMBL17801496 | 0.77 | ATIC (0.51) | ATICTHRB | |
| SCHEMBL17801523 | 0.75 | THRB (0.57) | ATICTHRB | |
| SCHEMBL17801500 | 0.74 | ATIC (0.54) | ATIC | |
| SCHEMBL17801458 | 0.73 | ATIC (0.46) | ATICTHRB | |
| SCHEMBL17801597 | 0.69 | ATIC (0.50) | ATICTHRB | |
| SCHEMBL17808402 | 0.68 | ATIC (0.68) | ATICTHRB | |
| SCHEMBL17801645 | 0.68 | ATIC (0.68) | ATICTHRB | |
| SCHEMBL17808576 | 0.68 | ATIC (0.68) | ATICTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227279-A1 | 1 -OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMIDE COMPOUNDS, FORMULATIONS CONTAINING THOSE COMPOUNDS, AND THEIR USE AS AICARFT INHIBITORS IN THE TREATMENT OF CANCERS | Eli Lilly and Company (US) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016089670-A1 | 1 -OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMIDE COMPOUNDS, FORMULATIONS CONTAINING THOSE COMPOUNDS, AND THEIR USE AS AICARFT INHIBITORS IN THE TREATMENT OF CANCERS | ELI LILLY AND COMPANY (US) | 2016-06-09 | — | — | WO | disclosed |