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SCHEMBL1780180

SCHEMBL1780180

CCOC(=O)n1nc(NC(=O)c2ccccc2N)c2cc(C(=O)NC(C)(C)c3ccccc3)sc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.38
▸ ABL1 P00519 2/20 0.38
▸ BCR P11274 2/20 0.38
▸ MAPT P10636 5/20 0.37
▸ TP53 P04637 2/20 0.37
▸ NPSR1 Q6W5P4 2/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ AURKA O14965 1/20 0.36
▸ ALDH1A1 P00352 5/20 0.35
▸ HPGD P15428 3/20 0.35
▸ MEN1 O00255 3/20 0.35
▸ KMT2A Q03164 3/20 0.35
▸ HSD17B10 Q99714 4/20 0.34
▸ PTGS1 P23219 1/20 0.34
▸ TACR3 P29371 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ CFTR P13569 1/20 0.34
▸ GAA P10253 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ PDE7A Q13946 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1780516 0.90 KDM4E (0.38) KDM4EMAPTTP53NPSR1SMN1; SMN2
SCHEMBL1779446 0.88 ALDH1A1 (0.43) KDM4EMAPTTP53NPSR1SMN1; SMN2
SCHEMBL12603552 0.88 KDM4E (0.37) KDM4EABL1BCRMAPTTP53
SCHEMBL1777102 0.87 AURKA (0.48) ABL1BCRAURKAPDE7A
SCHEMBL1777784 0.86 KDM4E (0.41) KDM4EMAPTTP53NPSR1SMN1; SMN2
SCHEMBL15372469 0.86 ALDH1A1 (0.39) KDM4EMAPTTP53SMN1; SMN2ALDH1A1
SCHEMBL738735 0.86 KDM4E (0.43) KDM4EMAPTTP53NPSR1SMN1; SMN2
SCHEMBL4633164 0.85 ABL1 (0.44) KDM4EABL1BCRMAPTTP53
SCHEMBL1778679 0.84 MAPT (0.37) KDM4EABL1BCRMAPTTP53
SCHEMBL740838 0.84 KDM4E (0.42) KDM4EABL1BCRMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904503-B1 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2013-11-06 — — EP disclosed
EP-1904503-B1 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2013-11-06 — — EP disclosed
US-7943654-B2 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-17 — — US disclosed
US-7943654-B2 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-17 — — US disclosed
US-20090149457-A1 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-06-11 — — US disclosed
US-20090149457-A1 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-06-11 — — US disclosed
WO-2007009898-A1 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-01-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090149457-A1 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors CCNH, PDK1, MAP3K5 KDM4E 2856/4885ABL1 397/4885BCR 1047/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.