Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 4/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17802004 | 0.84 | KMT2A (0.41) | ACKR3CHRNB4CHRNA3CYP1A2CYP2D6 | |
| SCHEMBL17801946 | 0.81 | ACKR3 (0.42) | ACKR3GRM2CHRNB4CHRNA3SIGMAR1 | |
| SCHEMBL19582241 | 0.81 | ACKR3 (0.43) | ACKR3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL17801898 | 0.77 | GRM2 (0.43) | ACKR3GRM2CHRNB4CHRNA3ACHE | |
| SCHEMBL19582257 | 0.76 | ACKR3 (0.40) | ACKR3GRM2SIGMAR1ACHECYP1A2 | |
| SCHEMBL19582463 | 0.75 | GRM2 (0.50) | ACKR3GRM2CHRNB4CHRNA3ACHE | |
| SCHEMBL17801896 | 0.72 | ACKR3 (0.57) | ACKR3 | |
| SCHEMBL8948801 | 0.71 | PARP1 (0.49) | ACHEKMT2A | |
| SCHEMBL10659420 | 0.68 | ALDH1A1 (0.42) | CHRNB4CHRNA3ACHEMEN1KMT2A | |
| SCHEMBL17802010 | 0.68 | GRM2 (0.50) | ACKR3GRM2CHRNB4CHRNA3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227263-A1 | CXCR7 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd (CH) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016087370-A1 | CXCR7 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-06-09 | — | — | WO | disclosed |