Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.62 |
| ▸ | KDR | P35968 | 5/20 | 0.62 |
| ▸ | JAK3 | P52333 | 2/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 8/20 | 0.49 |
| ▸ | SRC | P12931 | 8/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638437 | 0.85 | LCK (0.60) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL5488838 | 0.84 | MAP4K4 (0.61) | LCKKDRJAK3MAPK14MAP4K4 | |
| SCHEMBL2741576 | 0.83 | LCK (0.65) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL42089 | 0.83 | LCK (0.73) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL2632884 | 0.81 | LCK (0.57) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL12575968 | 0.81 | SRC (0.61) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL21416840 | 0.81 | LCK (0.55) | LCKKDRJAK3MAPK14MAP4K4 | |
| SCHEMBL5494272 | 0.78 | LCK (0.58) | LCKKDRJAK3MAPK14RAB9A | |
| SCHEMBL24335889 | 0.78 | PIK3CA (0.55) | LCKKDRJAK3MAPK14PDGFRA | |
| SCHEMBL13040 | 0.78 | MAP4K4 (0.66) | ADORA1MAP4K4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359349-B2 | Substituted quinazolines as kinase inhibitors | INTELLIKINE LLC (US) | 2016-06-07 | — | — | US | disclosed |