Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.55 |
| ▸ | TEK | Q02763 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17803857 | 0.81 | LCK (0.62) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5488838 | 0.80 | MAP4K4 (0.61) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL2741576 | 0.80 | LCK (0.65) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL12575968 | 0.78 | SRC (0.61) | LCKKDRJAK3MAPK14SRC | |
| SCHEMBL42089 | 0.76 | LCK (0.73) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5494272 | 0.75 | LCK (0.58) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL14568173 | 0.75 | LCK (0.76) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL24335889 | 0.75 | PIK3CA (0.55) | LCKKDRJAK3MAPK14MAPT | |
| SCHEMBL5496333 | 0.73 | LCK (0.59) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5498066 | 0.73 | LCK (0.59) | LCKKDRJAK3MAPK14TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |