Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.55 |
| ▸ | PI4KA | P42356 | 1/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2741576 | 0.83 | LCK (0.65) | PIK3CALCKKDRJAK3MAPK14 | |
| SCHEMBL3025007 | 0.82 | LCK (0.55) | PIK3CALCKKDRJAK3MAPK14 | |
| SCHEMBL5488838 | 0.81 | MAP4K4 (0.61) | LCKKDRJAK3MAPK14MEN1 | |
| SCHEMBL5494272 | 0.78 | LCK (0.58) | LCKKDRJAK3MAPK14MEN1 | |
| SCHEMBL17803857 | 0.78 | LCK (0.62) | LCKKDRJAK3MAPK14PDGFRA | |
| SCHEMBL12575968 | 0.78 | SRC (0.61) | PIK3CALCKKDRJAK3MAPK14 | |
| SCHEMBL30669824 | 0.78 | PIK3CA (0.62) | PIK3CAPIK3CDPIP5K1CPI4KAPI4KB | |
| SCHEMBL27892456 | 0.78 | PIK3CA (0.62) | PIK3CAPIK3CDPIP5K1CPI4KAPI4KB | |
| SCHEMBL21264426 | 0.77 | NPC1 (0.75) | PIK3CAPIK3CDPIP5K1CPI4KAPI4KB | |
| SCHEMBL30604173 | 0.77 | NPC1 (0.75) | PIK3CAPIK3CDPIP5K1CPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3395814-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2022-04-06 | — | — | EP | disclosed |