Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.55 |
| ▸ | EED | O75530 | 1/20 | 0.44 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.44 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.44 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.44 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18829901 | 0.84 | EZH2 (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13280225 | 0.84 | EZH2 (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13276998 | 0.81 | EZH2 (0.56) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL17804325 | 0.76 | EZH2 (0.42) | EZH2PDE4ANPC1MEN1KMT2A | |
| SCHEMBL17804355 | 0.76 | EZH2 (0.41) | EZH2 | |
| SCHEMBL13277238 | 0.74 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18829912 | 0.74 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13276540 | 0.74 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL29613562 | 0.74 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL30499098 | 0.73 | EZH2 (0.59) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697198-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2016-06-08 | — | — | EP | disclosed |