Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830027 | 0.83 | EZH2 (0.43) | EZH2NPSR1LMNAALDH1A1KMT2A | |
| SCHEMBL13279974 | 0.80 | OPRK1 (0.47) | EZH2NPSR1LMNAOPRK1 | |
| SCHEMBL17804350 | 0.76 | EZH2 (0.55) | EZH2KMT2AMEN1NPC1PDE4A | |
| SCHEMBL17804355 | 0.75 | EZH2 (0.41) | EZH2ALDH1A1TSHRHPGDALOX15 | |
| SCHEMBL18829848 | 0.71 | EZH2 (0.54) | EZH2NPSR1LMNAALDH1A1KMT2A | |
| SCHEMBL13280553 | 0.71 | EZH2 (0.54) | EZH2NPSR1ALDH1A1HSD17B10OPRK1 | |
| SCHEMBL13468019 | 0.71 | LMNA (0.39) | EZH2NPSR1LMNAALDH1A1NPC1 | |
| SCHEMBL13280798 | 0.70 | EZH2 (0.53) | EZH2NPSR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL18830052 | 0.70 | ALDH1A1 (0.40) | EZH2NPSR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL13280647 | 0.70 | GAA (0.44) | NPSR1ALDH1A1KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697198-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2016-06-08 | — | — | EP | disclosed |