Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 5/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 2/20 | 0.35 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155520 | 0.89 | L3MBTL1 (0.47) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12155451 | 0.83 | ALDH2 (0.44) | NPC1RAB9ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL1702038 | 0.83 | SMN1; SMN2 (0.52) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12156250 | 0.80 | SMN1; SMN2 (0.47) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12155795 | 0.80 | STIM1 (0.43) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12155931 | 0.77 | NPC1 (0.52) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12155512 | 0.77 | MAPT (0.43) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12155769 | 0.76 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL12155513 | 0.76 | NPC1 (0.42) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12241418 | 0.76 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563776-B1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC (US) | 2016-06-08 | — | — | EP | disclosed |